Dana Simiuc – SMMiL-E

Researcher at SATT NORD

LIMMS/CNRS-IIS, The University of Tokyo, Lille, France
SMMiL-E project

I am a curious young scientist, with a PhD in physics, having strong interest in working with a multidisciplinary research team, willing to share my experience in biophysics. Dynamics of biological systems related questions using imaging techniques and optofluidics are my particular research interests. Since April 2023, i’m involved in the ImmunoMEMS project, maturation phase with SATT NORD.

RESEARCH INTERESTS

Biophotonics
Optofluidics
Cellular fate: dynamics of cellular response to stress – high-throughput single cell approach

EDUCATION AND RESEARCH

2020: PhD in Physics, Biophysics group of stress, PhLAM, University of Lille, France
2015: Master degree in Biological and Medical Physics, Molecular Biophysics and Medical Physics Laboratory, Department of Physics, UAIC, Iasi, Romania
2015: Teaching Certification – Psycho Pedagogical Training, Teaching’s Training Department, UAIC, Iasi, Romania
2014: Erasmus Internship, Biophysics group of stress, PhLAM, University of Lille, France

PROFESSIONAL ACTIVITIES

2023-present : Developing engineer on IMMUNOMEMS project, LIMMS-IIS – SMMiL-E and SATT NORD.
2022 : Postdoc researcher, CNRS IRL2820 LIMMS-IIS – SMMiL-E project, vaisseau team
2022: Engineer on Photonic Microscopy Techniques, BICeL CS, UAR PLBS, University of Lille
2018–2020: Engineer in experimental techniques, Biophysics Group of Stress, PhLAM, University of Lille, France
2016-2019: Teaching – assistant researcher, IMT Lille Douai, France
Classes (practical work): Geometrical optics, Interference and diffraction, Oscillatory systems, Materials Physics
2015-2018: Research Assistant, Biophysics Group of Stress, PhLAM, University of Lille, France
2014-2015: Training in fundamental research Molecular Biophysics and Medical Physics Laboratory, Physics Department, Alexandru Ioan Cuza University from Iasi, Romania
2014: Training in fundamental research, Biophysics Group of Stress, PhLAM, University of Lille, France; UAIC, Iasi, Romania

SELECTED ONGOING PROJECTS

I am currently working in BioPharMEMS project, partnership between LIMMS SMMiL-E project, HCS Pharma and IEMN, in Lille France. In this context I am asking how vascular targeting therapies can be exploited to treat tumours. It is well known that blood vessels are adapting, favouring the tumour growth. Our experimental approach is to build in vitro human blood vessels in a biocompatible matrix. We design μfluidic chambers in PDMS and use a sacrificial template approach, to form a perfused, stable blood vessel using primary human endothelial cells. Cells are grown in a proprietary matrix which makes a controlled 3D environment. As perspective, we wish to recreate a tumour in this matrix and perfuse it through the established blood vessel.

SELECTED PUBLICATIONS

D. Simiuc, F. Anquez, A. Treizebre, E. Vandenhaute, Z. Souguir, F. Soncin, E. Courtade, Adaptation: from molecular dynamics in single cells to organs on-a-chip approaches,1^st ONCOLille Days, November 2022, Lille, France p.57
D. Simiuc, F. Anquez, Q. Thommen, B. Pfeuty, E. Courtade, Adaptation of breast cancer cells : variability of single cells responses, 1^st ONCOLille Days, November 2022, Lille, France, p54
D. Simiuc, F. Dahmani, A. Pruvost, M. Guilbert, M. Brulé, C. Lagadec, B. Pfeuty, Q. Thommen, E. Courtade and F. Anquez. Measuring adaptation dynamics to hydrogen peroxide in single human cells using genetically encoded fluorescent probes, DOI 10.1101/2020.11.14.382911, (online submission 2020)
E-F. Grosu, D. Simiuc and R. Froidevaux. Layered Double Hydroxides Nanomaterials in Biomedicine and (bio) Sensing Design. BJSTR, Vol2, Issue 4, DOI 10.26717/BJSTR.2018.02.000786 (2018)
D. Simiuc, A. Pruvost, S. Demolin, F. Anquez, and E. Courtade, Dynamics of ROS scavenging and cell death: A system biology approach, 41^st FEBS advanced courses: Redox regulation of metabolic processes, September 19^th–25^th, 2016, Spetses, Greece