The scientific activities encompass BioMEMS research against Cancer – technology development and bio related experiments – as an original interdisciplinary approach to the SIRIC ONCO-Lille program. The projects aims to bridge fundamental and clinical research around 4 work packages related to the scale of transferred biotechnologies:
WP1 : Resistance in biomolecular mechanism
- DNA degradation under X-ray (radiotherapy)
- Molecules interaction dynamics (chemotherapy)
Application : Therapy and combined therapies
WP2 : Cellular evaluation and diagnosis
- Cell sorting, Circulating tumor cells, Stem cells
- Cellular senescence and tumoral resistance
Application : Diagnosis, Therapy monitoring
WP3 : Tumors and therapeutic targets
- Development of tumor angiogenesis
- Cellular motilify and metastatic processes
Application : Mechanism of action, drug evaluation
WP4 : Biological adhesives and neotissues
- Biological glues, cellular fibers
- Patch and new-tissues
Application : Reconstructive surgery
By means of an upstream research, this program targets more effective disease detection, a strengthened efficacy of therapy and post-treatment monitoring, for a better care to patient.
- L. Bresson, E. Leblanc, A. S. Lemaire, T. Okitsu, F. Chai, “Autologous peritoneal grafts permit rapid reperitonealization and prevent postoperative abdominal adhesions in an experimental rat study”, Surgery, Vol. 162, pp. 863-870, 2017.
- G. Perret, T. Lacornerie, F. Manca, S. Giordano, M. Kumemura, N. Lafitte, L. Jalabert, M. C. Tarhan, E. Lartigau, F. Cleri, H. Fujita and D. Collard, “Real-time mechanical characterization of DNA degradation under therapeutic X-rays and its theoretical modeling”, Microsystems & Nanoengineering, Vol. 2, p. 16062, 2016.
- G. Perret, P. Ginet, M.C. Tarhan, A. Baccouche, T. Lacornerie, M. Kumemura, L. Jalabert, F. Cleri, E.F. Lartigau, B.J. Kim, S.L. Karsten, H. Fujita, Y. Rondelez, T. Fujii, D. Collard, “Nano systems and devices for applications in biology and nanotechnology”, Solid-State Electronics, Vol.115, pp.66–73, 2016.