Work Packages

The scientific activities encompass BioMEMS research against Cancer – technology development and bio related experiments – as an original interdisciplinary approach to the SIRIC ONCO-Lille program. The projects aims to bridge fundamental and clinical research around 4 work packages related to the scale of transferred biotechnologies:

WP1 : Resistance in biomolecular mechanism

  • DNA degradation under X-ray (radiotherapy)
  • Molecules interaction dynamics (chemotherapy)

Application : Therapy and combined therapies

WP2 : Cellular evaluation and diagnosis

  • Cell sorting, Circulating tumor cells, Stem cells
  • Cellular senescence and tumoral resistance

Application : Diagnosis, Therapy monitoring

WP3 : Tumors and therapeutic targets

  • Development of tumor angiogenesis
  • Cellular motilify and metastatic processes

Application : Mechanism of action, drug evaluation

WP4 : Biological adhesives and neotissues

  • Biological glues, cellular fibers
  • Patch and new-tissues

Application : Reconstructive surgery

 

By means of an upstream research, this program targets more effective disease detection, a strengthened efficacy of therapy and post-treatment monitoring, for a better care to patient.


 

 

Publications

2017

  1. L. Bresson, E. Leblanc, A. S. Lemaire, T. Okitsu, F. Chai, “Autologous peritoneal grafts permit rapid reperitonealization and prevent postoperative abdominal adhesions in an experimental rat study”, Surgery, Vol. 162, pp. 863-870, 2017.

2016

  1. G. Perret, T. Lacornerie, F. Manca, S. Giordano, M. Kumemura, N. Lafitte, L. Jalabert, M. C. Tarhan, E. Lartigau, F. Cleri, H. Fujita and D. Collard, “Real-time mechanical characterization of DNA degradation under therapeutic X-rays and its theoretical modeling”, Microsystems & Nanoengineering, Vol. 2, p. 16062, 2016.
  2. G. Perret, P. Ginet, M.C. Tarhan, A. Baccouche, T. Lacornerie, M. Kumemura, L. Jalabert, F. Cleri, E.F. Lartigau, B.J. Kim, S.L. Karsten, H. Fujita, Y. Rondelez, T. Fujii, D. Collard, “Nano systems and devices for applications in biology and nanotechnology”, Solid-State Electronics, Vol.115, pp.66–73, 2016.