PhD student 

Supervisors: Fabrice SONCIN

LIMMS/CNRS-IIS, The University of Tokyo, Lille, France
SMMiL-E project

Contact: hezili.ibtihal(at)smmil-e.com

RESEARCH INTERESTS

  • Organs-on-chip, Blood vessels-on-chip
  • Angiogenesis
  • Microfluidics
  • Microperfusion

EDUCATION

  • 2021 – 2023 – MSc, Life Sciences & Technologies – Université de Lille, France.
  • 2017 – 2020 – Double diploma (Eng. + MSc), Biotechnology & Health – Ecole Nationale Supérieure de Biotechnologie, Algeria.
  • 2015 – 2017 – Integrated preparatory classes – Ecole Nationale Supérieure de Biotechnologie, Algeria.

PROFESSIONAL ACTIVITIES

  • 2023 – Research Internship – Biosensors (CBio), Electronic & Electrical Engineering Dept., University of Bath, United-Kingdom.
  • 2022 – Research Internship – Microfluidics & Vessels-on-Chip, LIMMS/CNRS-IIS SMMiL-E project, Lille, France.
  • 2022 – Research Internship – Nanoneedles Fabrication, IEMN, Villeneuve-d’ascq, France.
  • 2019 – Lab Internship – DNA profiling, Institut National de Criminalistique et Criminologie, Algiers, Algeria.
  • 2019 – Lab Internship – Flow Cytometry for immune disease diagnostic, Immunology Dept., Institut Pasteur d’Alger, Algiers, Algeria.

SELECTED ONGOING PROJECTS

  • Blood vessels-on-Chip for the study of the effects of anti-cancer therapies on angiogenesis – University of Lille, France.

The vascular system is a complex network of blood vessels that supply organs with oxygen and nutrients, and transport immune cells, among other functions. In the context of cancer, the formation of blood vessels by angiogenesis promotes tumour growth and metastasis. Immuno- and anti-angiogenic therapies are now part of the classical arsenal of treatments that directly affect the functions of blood vessels in cancer patients. This project aims to create and biologically validate new models of vessels-on-a-chip (VoC) to study the effects of treatments currently used in the clinic on the formation of new blood vessels by angiogenesis. Its final goals are to make a lung model of “angiogenic-VoC”, with an initial 3D blood vessel made of human pulmonary endothelial cells, including or not perivascular cells, established in a microfluidic channel with a lateral inlet used for angiogenic stimulation. The effects of immuno- and anti-angiogenic therapies, combined or not, on the angiogenic sprouts will be evaluated to understand the underlying molecular mechanisms of this process under treatments.

Keywords —  Blood vessels, organ-on-chip, angiogenesis, microfluidics, cancer, therapies.